Kuo PC, Weng WT, Scofiled BA, Paraiso HP, Bojrab P, Kimes B, Yu ICI, Yen JHJ. Interferon-beta Modulates Microglial Polarization to Ameliorate Delayed tPA-Exacerbated Brain Injury in Ischemic Stroke. Front Immunol. 2023 Mar 31;14:1148069. PMID: 37063896
Yen JHJ, Yu ICI. The role of ApoE-mediated microglial lipid metabolism in brain aging and disease. Immunometabolism. 2023 Jan 23;5(1): e00018. PMID: 36710921
Weng WT, Kuo PC, Scofield BA, Paraiso HC, Brown DA, Yu IC, Yen JH. 4-Ethylguaiacol modulates neuroinflammation and promotes heme oxygenase-1 expression to ameliorate brain injury in ischemic stroke. Front Immunol. 2022 Jul 1; 13:887000. PMID: 35860274
Kuo PC, Weng WT, Scofield BA, Paraiso HC, Yu IC, Yen JH. Immunoresponsive gene 1 modulates the severity of brain injury in cerebral ischemia. Brain Communications. 2021. Aug 19;3(3): fcab187. PMID: 34557667
Weng WT, Kuo PC, Brown DA, Scofield BA, Furnas D, Paraiso HC, Wang PY, Yu IC, Yen JH. 4-Ethylguaiacol modulates neuroinflammation and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis. J. Neuroinflammation. 2021. May 11;18(1):110. PMID: 33975618
Kuo PC, Weng WT, Scofield BA, Furnas D, Paraiso HC, Intriago AJ, Bosi KD, Yu IC, Yen JH. Interferon-β alleviates delayed tPA-induced adverse effects via modulation of MMP3/9 production in ischemic stroke. Blood Adv. 2020 Sep 22;4(18):4366-4381. PMID: 32926126
Kuo PC, Weng WT, Scofield BA, Paraiso HC, Brown DA, Wang PY, Yu IC, Yen JH. Dimethyl Itaconate, an Itaconate Derivative, Exhibits Immunomodulatory Effects on Neuroinflammation in Experimental Autoimmune Encephalomyelitis. J. Neuroinflammation. 2020 Apr 29;17(1):138. PMID: 32349768
Paraiso HC, Wang X, Kuo PC, Furnas D, Scofield BA, Chang FL, Yen JH, Yu IC. Isolation of Mouse Cerebral Microvasculature for Molecular and Single-Cell Analysis. Front Cell Neurosci. 2020 Apr 9; 14:84. PMID: 32327974
Han J, Nalam VJ, Yu IC, Nachappa P. Vector Competence of Thrips Species to Transmit Soybean Vein Necrosis Virus. Front Microbiol. 2019 Mar 19; 10:431. PMID: 30941106
Paraiso HC, Kuo PC, Curfman ET, Moon HJ, Sweazey RD, Yen JH, Chang, FL, Yu IC. Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge. J. Neuroinflammation. 2018 Mar 29;15 (1):100. PMID: 29598822
Kuo PC, Brown DA, Scofield BA, Paraiso HC, Wang PY, Yu IC, Yen JH. Dithiolethione ACDT Suppresses Neuroinflammation and Ameliorates Disease Severity in Experimental Autoimmune Encephalomyelitis. Brain Behav Immun. 2018 Mar 28. pii: S0889-1591(18)30058-8. doi: 10.1016/j.bbi.2018.03.010. PMID: 29604346
Yu IC, Yen JH, Kuo PC, Paraiso HC, Hong-Goka BC, Sweazey RD, Chang FL. A combination of three repurposed drugs administered at the time of reperfusion as a promising therapy for post-ischemic brain injury. Transl Stroke Res. 2017 Jun 17. doi: 10.1007/s12975-017-0543-5. PMID: 28624878
Kuo PC, Yu IC, Scofield BA, Brown DA, Curfman ET, Paraiso HC, Chang FL, Yen JH. 3H-1,2-Dithiole-3-Thione as a novel therapeutic agent for the treatment of ischemic stroke through Nrf2 defense pathway. Brain Behav Immun. 2017 May;62:180-192. PMID: 28132764
Kuo PC, Brown DA, Scofield BA, Yu IC, Chang FL, Wang PY, Yen JH. 3H-1,2-Dithiole-3-thione as a novel therapeutic agent for the treatment of experimental autoimmune encephalomyelitis. Brain Behav Immun. 2016 Oct;57:173-86. PMID: 27013356
Kuo PC, Scofield BA, Yu IC, Chang FL, Ganea D, Yen JH. IFNbeta modulates inflammatory responses in cerebral ischemia. Journal of the American Heart Association. 2016. Jan 8;5(1). pii: e002610. PMID: 26747000
Yu IC, Lin HY, Sparks JD, Yeh S, Chang C. Roles of androgen receptor in insulin resistance and obesity in males: the linkage of androgen deprivation therapy to the metabolic syndrome. Diabetes. 2014. Oct; 63(10):3180-8. PMID: 25249645
Yu IC, Lin HY, Liu NC, Sparks JD, Yeh S, Fang LY, Chang C. Neuronal androgen receptor regulates insulin sensitivity via suppression of hypothalamic NF-κB-mediated PTP1B expression. Diabetes. 2013 Feb; 62(2):411-23. PMID: 23139353
Kim E, Liu NC, Yu IC, Lin HY, Lee YF, Sparks JD, Chen LM, Chang C. Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-coenzyme A desaturase 1 gene expression with altered insulin sensitivity. Diabetes. 2011 May; 60(5):1493-503. PMID: 21478464
Lai JJ, Lai KP, Chuang KH, Chang P, Yu IC, Lin WJ, Chang C. Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNFa expression. J. Clin. Invest. 2009 Dec; 119(12):3739-51. PMID: 19907077
Liu NC, Lin WJ, Yu IC, Lin HY, Liu S, Lee YF, Chang C. Activation of TR4 orphan nuclear receptor gene promoter by cAMP/PKA and C/EBP signaling. Endocrine. 2009 Oct; 36(2):211-7. PMID: 19618297
Lin HY, Yu IC, Wang RS, Chen YT, Liu NC, Altuwaijri S, Hsu CL, Ma WL, Jokinen J, Sparks JD, Yeh S, Chang C. Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor. Hepatology. 2008 Jun; 47 (6):1924-35. PMID: 18449947
Yu IC, Lin HY, Liu NC, Wang RS, Sparks JD, Yeh S, Chang C. Hyperleptinemia without obesity in male mice lacking androgen receptor in adipose tissue. Endocrinology. 2008 May; 149 (5):2361-8. PMID: 18276764
Xu Q, Lin HY, Yeh SD, Yu IC, Wang RS, Chen YT, Zhang C, Altuwaijri S, Chen LM, Chuang KH, Chiang HS, Yeh S, Chang C. Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking androgen receptor in leydig cells. Endocrine. 2007 Aug; 32 (1):96-106. PMID: 17955388
Liu NC, Lin WJ, Kim E, Collins LL, Lin HY, Yu IC, Sparks JD, Chen LM, Lee YF, Chang C. Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis. Diabetes. 2007 Dec; 56 (12):2901-9. PMID: 17827404
Huang C, Chang SC, Yu IC, Tsay YG, Chang MF. Large hepatitis delta antigen is a novel clathrin adaptor-like protein. J. Virol. 2007 Jun; 81 (11):5985-94. PMID: 17376909
Yang Z, Chang YJ, Yu, IC, Yeh S, Wu CC, Miyamoto H, Merry DE, Sobue G, Chen LM, Chang SS, Chang C. ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. Nat. Med. 2007 Mar; 13 (3):348-53. PMID: 17334372
Yen JHJ, Yu ICI. The role of ApoE-mediated microglial lipid metabolism in brain aging and disease. Immunometabolism. 2023 Jan 23;5(1): e00018. PMID: 36710921
Weng WT, Kuo PC, Scofield BA, Paraiso HC, Brown DA, Yu IC, Yen JH. 4-Ethylguaiacol modulates neuroinflammation and promotes heme oxygenase-1 expression to ameliorate brain injury in ischemic stroke. Front Immunol. 2022 Jul 1; 13:887000. PMID: 35860274
Kuo PC, Weng WT, Scofield BA, Paraiso HC, Yu IC, Yen JH. Immunoresponsive gene 1 modulates the severity of brain injury in cerebral ischemia. Brain Communications. 2021. Aug 19;3(3): fcab187. PMID: 34557667
Weng WT, Kuo PC, Brown DA, Scofield BA, Furnas D, Paraiso HC, Wang PY, Yu IC, Yen JH. 4-Ethylguaiacol modulates neuroinflammation and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis. J. Neuroinflammation. 2021. May 11;18(1):110. PMID: 33975618
Kuo PC, Weng WT, Scofield BA, Furnas D, Paraiso HC, Intriago AJ, Bosi KD, Yu IC, Yen JH. Interferon-β alleviates delayed tPA-induced adverse effects via modulation of MMP3/9 production in ischemic stroke. Blood Adv. 2020 Sep 22;4(18):4366-4381. PMID: 32926126
Kuo PC, Weng WT, Scofield BA, Paraiso HC, Brown DA, Wang PY, Yu IC, Yen JH. Dimethyl Itaconate, an Itaconate Derivative, Exhibits Immunomodulatory Effects on Neuroinflammation in Experimental Autoimmune Encephalomyelitis. J. Neuroinflammation. 2020 Apr 29;17(1):138. PMID: 32349768
Paraiso HC, Wang X, Kuo PC, Furnas D, Scofield BA, Chang FL, Yen JH, Yu IC. Isolation of Mouse Cerebral Microvasculature for Molecular and Single-Cell Analysis. Front Cell Neurosci. 2020 Apr 9; 14:84. PMID: 32327974
Han J, Nalam VJ, Yu IC, Nachappa P. Vector Competence of Thrips Species to Transmit Soybean Vein Necrosis Virus. Front Microbiol. 2019 Mar 19; 10:431. PMID: 30941106
Paraiso HC, Kuo PC, Curfman ET, Moon HJ, Sweazey RD, Yen JH, Chang, FL, Yu IC. Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge. J. Neuroinflammation. 2018 Mar 29;15 (1):100. PMID: 29598822
Kuo PC, Brown DA, Scofield BA, Paraiso HC, Wang PY, Yu IC, Yen JH. Dithiolethione ACDT Suppresses Neuroinflammation and Ameliorates Disease Severity in Experimental Autoimmune Encephalomyelitis. Brain Behav Immun. 2018 Mar 28. pii: S0889-1591(18)30058-8. doi: 10.1016/j.bbi.2018.03.010. PMID: 29604346
Yu IC, Yen JH, Kuo PC, Paraiso HC, Hong-Goka BC, Sweazey RD, Chang FL. A combination of three repurposed drugs administered at the time of reperfusion as a promising therapy for post-ischemic brain injury. Transl Stroke Res. 2017 Jun 17. doi: 10.1007/s12975-017-0543-5. PMID: 28624878
Kuo PC, Yu IC, Scofield BA, Brown DA, Curfman ET, Paraiso HC, Chang FL, Yen JH. 3H-1,2-Dithiole-3-Thione as a novel therapeutic agent for the treatment of ischemic stroke through Nrf2 defense pathway. Brain Behav Immun. 2017 May;62:180-192. PMID: 28132764
Kuo PC, Brown DA, Scofield BA, Yu IC, Chang FL, Wang PY, Yen JH. 3H-1,2-Dithiole-3-thione as a novel therapeutic agent for the treatment of experimental autoimmune encephalomyelitis. Brain Behav Immun. 2016 Oct;57:173-86. PMID: 27013356
Kuo PC, Scofield BA, Yu IC, Chang FL, Ganea D, Yen JH. IFNbeta modulates inflammatory responses in cerebral ischemia. Journal of the American Heart Association. 2016. Jan 8;5(1). pii: e002610. PMID: 26747000
Yu IC, Lin HY, Sparks JD, Yeh S, Chang C. Roles of androgen receptor in insulin resistance and obesity in males: the linkage of androgen deprivation therapy to the metabolic syndrome. Diabetes. 2014. Oct; 63(10):3180-8. PMID: 25249645
Yu IC, Lin HY, Liu NC, Sparks JD, Yeh S, Fang LY, Chang C. Neuronal androgen receptor regulates insulin sensitivity via suppression of hypothalamic NF-κB-mediated PTP1B expression. Diabetes. 2013 Feb; 62(2):411-23. PMID: 23139353
Kim E, Liu NC, Yu IC, Lin HY, Lee YF, Sparks JD, Chen LM, Chang C. Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-coenzyme A desaturase 1 gene expression with altered insulin sensitivity. Diabetes. 2011 May; 60(5):1493-503. PMID: 21478464
Lai JJ, Lai KP, Chuang KH, Chang P, Yu IC, Lin WJ, Chang C. Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNFa expression. J. Clin. Invest. 2009 Dec; 119(12):3739-51. PMID: 19907077
Liu NC, Lin WJ, Yu IC, Lin HY, Liu S, Lee YF, Chang C. Activation of TR4 orphan nuclear receptor gene promoter by cAMP/PKA and C/EBP signaling. Endocrine. 2009 Oct; 36(2):211-7. PMID: 19618297
Lin HY, Yu IC, Wang RS, Chen YT, Liu NC, Altuwaijri S, Hsu CL, Ma WL, Jokinen J, Sparks JD, Yeh S, Chang C. Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor. Hepatology. 2008 Jun; 47 (6):1924-35. PMID: 18449947
Yu IC, Lin HY, Liu NC, Wang RS, Sparks JD, Yeh S, Chang C. Hyperleptinemia without obesity in male mice lacking androgen receptor in adipose tissue. Endocrinology. 2008 May; 149 (5):2361-8. PMID: 18276764
Xu Q, Lin HY, Yeh SD, Yu IC, Wang RS, Chen YT, Zhang C, Altuwaijri S, Chen LM, Chuang KH, Chiang HS, Yeh S, Chang C. Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking androgen receptor in leydig cells. Endocrine. 2007 Aug; 32 (1):96-106. PMID: 17955388
Liu NC, Lin WJ, Kim E, Collins LL, Lin HY, Yu IC, Sparks JD, Chen LM, Lee YF, Chang C. Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis. Diabetes. 2007 Dec; 56 (12):2901-9. PMID: 17827404
Huang C, Chang SC, Yu IC, Tsay YG, Chang MF. Large hepatitis delta antigen is a novel clathrin adaptor-like protein. J. Virol. 2007 Jun; 81 (11):5985-94. PMID: 17376909
Yang Z, Chang YJ, Yu, IC, Yeh S, Wu CC, Miyamoto H, Merry DE, Sobue G, Chen LM, Chang SS, Chang C. ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. Nat. Med. 2007 Mar; 13 (3):348-53. PMID: 17334372